Bioavailability of bacampicillin and talampicillin, two oral prodrugs of ampicillin.
نویسندگان
چکیده
A 200-mg amount of bacampicillin showed a significantly higher relative extent of bioavailability than did a 250-mg amount of talampicillin, possibly due to their different stability in the digestive juices.
منابع مشابه
Biol. Pharm. Bull. 30(7) 1344—1349 (2007)
amino b-lactam antibiotic. As with other ampicillin prodrugs such as pivampicillin and talampicillin, bacampicillin was developed almost 30 years ago under the hypothesis that the addition of a lipophilic moiety to the hydrophilic ampicillin molecule would improve intestinal absorption of the parent drug. It has been reported that ampicillin exhibits 33—54% bioavailability after oral administra...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 20 6 شماره
صفحات -
تاریخ انتشار 1981